It is believed that during first-pass metabolism and subsequent passes through the liver, 4-AcO-DMT/psilacetin is deacetylated into psilocin in the body (evident as 5 MEO DALT is also active when injected). This is based on reports that most users cannot identify the difference between these two chemicals when they are ingested to the point that they are frequently believed to be indistinguishable from each other in terms of their subjective effects, but it has not been scientifically confirmed.

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